Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vps13ctm1.1Geno
Name:	vacuolar protein sorting 13C; targeted mutation 1.1, Genoway
MGI ID:	MGI:5907128
Synonyms:	Vps13cfl
Gene:	Vps13c  Location: Chr9:67747678-67902920 bp, + strand  Genetic Position: Chr9, 36.77 cM
Alliance:	Vps13ctm1.1Geno page

Germline Transmission:	Earliest citation of germline transmission: J:241413
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: LoxP sites were inserted upstream of exon 1 and in intron 1. This creates a conditional-ready allele with exon 1 floxed. Exon 1 contains the translation start site and its deletion would create a null allele. An FRT site flanked neomycin resistance gene cassette that was inserted into intron 1 was removed through flp-mediated recombination. (J:241413)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vps13c Mutation:	169 strains or lines available

Original:	J:241413 Mehta ZB, et al., Changes in the expression of the type 2 diabetes-associated gene VPS13C in the beta-cell are associated with glucose intolerance in humans and mice. Am J Physiol Endocrinol Metab. 2016 Aug 01;311(2):E488-507
All:	1 reference(s)