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Ptgs1tm1.1Hahe
Targeted Allele Detail
Summary
Symbol: Ptgs1tm1.1Hahe
Name: prostaglandin-endoperoxide synthase 1; targeted mutation 1.1,Harvey R Herschman
MGI ID: MGI:5906230
Synonyms: Cox-1flox
Gene: Ptgs1  Location: Chr2:36120438-36142284 bp, + strand  Genetic Position: Chr2, 24.19 cM
Alliance: Ptgs1tm1.1Hahe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  LW1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe targeting vector is designed to insert a single loxP site upstream of exon 3 and a single loxP site downstream of exon 5 of the gene. An FRT-flanked neomycin resistance (neo) cassette is inserted between exons 2 and 3. The neo cassette was deleted by transiently transfection of an expression vector of flp recombinase expression plasmid in the ES cells. (J:101977)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptgs1 Mutation:  45 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/22/2025
MGI 6.24
The Jackson Laboratory