Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Taco1m1Anu
Name:	translational activator of mitochondrially encoded cytochrome c oxidase I; ENU mutation 1, Australian National University
MGI ID:	MGI:5905291
Synonyms:	Taco1m1Apb, Taco1mut
Gene:	Taco1  Location: Chr11:105956887-105964438 bp, + strand  Genetic Position: Chr11, 68.89 cM, cytoband E1
Alliance:	Taco1m1Anu page

Strain of Origin:	C57BL/6NCrlAnu
Project Collection:	APF ENU Mutagenesis

Allele Type:    Chemically induced (ENU) (Null/knockout) Mutation:    Single point mutation   Mutation details: ENU treatment caused a T491A substitution in exon 3, which changes isoleucine codon 164 into an asparagine codon (p.Ile164Asn). Ile164 is a conserved residue and in homozygous mice virtually no protein is detected in liver and heart mitochondria via immunoblotting. (J:239883)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Taco1 Mutation:	20 strains or lines available

Original:	J:239883 Richman TR, et al., Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun. 2016 Jun 20;7:11884
All:	2 reference(s)