Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Umodem1(cre/ERT2)Amc
Name:	uromodulin; endonuclease-mediated mutation 1, Andrew P McMahon
MGI ID:	MGI:5902999
Synonyms:	Umod-IRES-CRE-ERT2
Gene:	Umod  Location: Chr7:119061931-119078485 bp, - strand  Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
Alliance:	Umodem1(cre/ERT2)Amc page

Germline Transmission:	Earliest citation of germline transmission: J:159099
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Umodem1(cre/ERT2)Amc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Umod (MGI:102674)   Mutation details: Plasmids encoding a signal guide RNA designed to introduce a cre/ERT2 knock-in mutation into 3' UTR near the stop codon of the Umod gene and the cas9 nuclease were introduced into the cytoplasm of C57BL/6N-derived JM8.N4 ES cells. (J:159099)

Activity:	Tissue activity of this recombinase allele
Driver:	Umod (mouse) Summary of all recombinase alleles driven by Umod. Alliance mouse Umod gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Umod Mutation:	4 strains or lines available

Original:	J:159099 McMahon A, et al., Summary of mouse strains characterized by GUDMAP consortium. Unpublished. 2010;
All:	2 reference(s)