Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ube2ohem9
Name:	ubiquitin-conjugating enzyme E2O; haematopoietic 9
MGI ID:	MGI:5902131
Synonyms:	hem9, Ube2oE1121X
Gene:	Ube2o  Location: Chr11:116428566-116472273 bp, - strand  Genetic Position: Chr11, 81.42 cM
Alliance:	Ube2ohem9 page

Strain of Origin:

C57BL/6J

Allele Type:    Chemically induced (ENU) (Null/knockout) Mutation:    Nucleotide substitutions   Mutation details: This allele was identified in a screen for a metabolic and haematopoietic phenotype described as hypochromic, microcytic anemia associated with erythrocytosis using ENU-treated C57BL/6J males (G0). Sequencing identified a G to T substitution, resulting in a E1121X (changing glutamic acid to a termination codon) mutation in the Ube2o gene. The mutation causes truncation of the C-terminal 168 amino acids and is a loss-of-function mutation. No gene product (protein) is detected by western blot analysis of blood. (J:243727)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ube2o Mutation:	57 strains or lines available

Original:	J:243727 Nguyen AT, et al., UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017 Aug 04;357(6350)
All:	1 reference(s)