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Gene Expression Data
Assay Details
Assay
Reference: J:46130 Nakayama A, et al., Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently. Mech Dev. 1998 Jan;70(1-2):155-66
Assay type: RNA in situ
MGI Accession ID: MGI:5898553
Gene symbol: Dct
Gene name: dopachrome tautomerase
Probe: clone p5A7
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 3A: embryonic day 11.5 (more )
Note: Parasagittal section through otic vesicle. Double labeled: red - Dct; blue - Mitf (assay MGI:5898480).
Structure Level Pattern Image Note
TS19: head mesenchyme derived from neural crest Present Regionally restricted 3A Authors report expression in majority of Mitf-expressing cells.
Specimen 3B: embryonic day 11.5 (more )
Note: Double labeled: red - Dct; blue - Mitf (assay MGI:5898480).
Structure Level Pattern Image Note
TS19: trunk mesenchyme derived from neural crest Present Regionally restricted 3B In the trunk, authors report overlap of Dct and Mtif expression in majority of more lateral cells, but not in those closer to dorsal midline.
Specimen 3C: embryonic day 11.5 (more )
Note: Double labeled: red - Dct; blue - Mitf (assay MGI:5898480).
Structure Level Pattern Image Note
TS19: tail mesenchyme derived from neural crest Present Regionally restricted 3C Overlap of Mitf and Dct expression away from midline.
Specimen 7F: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: hair follicle Present 7F
TS27: iris Present 7F
TS27: pigmented retinal epithelium Present 7F
Specimen 7H: postnatal newborn; Mitfmi-ew/Mitfmi-ew (more )
Structure Level Pattern Image Note
TS27: hair follicle Absent 7H
TS27: iris Present Regionally restricted 7H xpression retained in retinal pigmented epithelium-derived (back) layer of iris.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
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