Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gcgtm1.1(cre/ERT2)Gkg
Name:	glucagon; targeted mutation 1.1, George K Gittes
MGI ID:	MGI:5898440
Synonyms:	GcgCreER2, Gcgtm1(cre/ERT2)Cshi
Gene:	Gcg  Location: Chr2:62304874-62313994 bp, - strand  Genetic Position: Chr2, 35.85 cM
Alliance:	Gcgtm1.1(cre/ERT2)Gkg page

Germline Transmission:	Earliest citation of germline transmission: J:256199
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Gcgtm1.1(cre/ERT2)Gkg expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Gcg (MGI:95674)   Mutation details: The targeting construct is designed to insert a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) followed by an SV40 polyadenylation signal, and a FRT-flanked neomycin resistance (neo) cassette into exon 2 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:256199)

Activity:	Tissue activity of this recombinase allele
Driver:	Gcg (mouse) Summary of all recombinase alleles driven by Gcg. Alliance mouse Gcg gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gcg Mutation:	32 strains or lines available

Original:	J:256199 Shiota C, et al., Gcg (CreERT2) knockin mice as a tool for genetic manipulation in pancreatic alpha cells. Diabetologia. 2017 Dec;60(12):2399-2408
All:	5 reference(s)