Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Trem2tm1c(EUCOMM)Wtsi
Name:	triggering receptor expressed on myeloid cells 2; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID:	MGI:5897643
Gene:	Trem2  Location: Chr17:48653429-48659304 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Alliance:	Trem2tm1c(EUCOMM)Wtsi page
IMPC:	Trem2 gene page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	JM8A1.N3 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	EUCOMM

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: The L1L2_Bact_P cassette was inserted at position 48543421 of Chromosome 17 upstream of exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted upstream of exon 4 at position 48544785. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele. (J:173534)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trem2 Mutation:	65 strains or lines available

Original:	J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:	5 reference(s)