Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Sox10-cre)1Sout
Name:	transgene insertion 1, E Southard-Smith
MGI ID:	MGI:5897484
Synonyms:	Sox10-CrehGH, Tg(Sox10-CrehGH)1Sout
Transgene:	Tg(Sox10-cre)1Sout  Location: unknown
Alliance:	Tg(Sox10-cre)1Sout page

Strain of Origin:

(C57BL/6 x SJL)F2

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Sox10-cre)1Sout expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note Not Specified Sox10   Mutation details: Using the BAC containing Sox10 regulatory regions, a nuclear localization sequence-modified Cre recombinase gene and a fragment from the human growth hormone gene was inserted directly downstream of the transcription initiation site. LoxP sites in the BAC flanking arms were removed prior to microinjection. The Sox10 regulatory regions drives neural crest-specifc expression of Cre recombinase. (J:240668)

Activity:	Tissue activity of this recombinase allele
Driver:	Sox10 (species not specified) Summary of all recombinase alleles driven by Sox10.

In Mice Carrying this Mutation:

26 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:240668 Musser MA, et al., Enteric neuron imbalance and proximal dysmotility in ganglionated intestine of the Sox10Dom/+ Hirschsprung mouse model. Cell Mol Gastroenterol Hepatol. 2015 Jan 01;1(1):87-101
All:	3 reference(s)