Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Foxp2tm1.1(cre)Rpa
Name:	forkhead box P2; targeted mutation 1.1, Richard D Palmiter
MGI ID:	MGI:5896307
Synonyms:	Foxp2Cre
Gene:	Foxp2  Location: Chr6:14901348-15441976 bp, + strand  Genetic Position: Chr6, 6.49 cM, cytoband A2
Alliance:	Foxp2tm1.1(cre)Rpa page

Germline Transmission:	Earliest citation of germline transmission: J:235958
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Foxp2tm1.1(cre)Rpa expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Foxp2 (MGI:2148705)   Mutation details: IRES-Myc tag-nuclear localization signal (NLS)-cre-GFP-frt-neomycin-frt were introduced just after the termination codon of the mouse Foxp2 gene via homologous recombination. The neomycin cassette was excised through crosses with animals broadly expressing Flp recombinase. The GFP is believed to be nonfunctional. (J:235958)

Activity:	Tissue activity of this recombinase allele
Driver:	Foxp2 (mouse) Summary of all recombinase alleles driven by Foxp2. Alliance mouse Foxp2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxp2 Mutation:	52 strains or lines available

Original:	J:235958 Rousso DL, et al., Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. Cell Rep. 2016 May 31;15(9):1930-44
All:	18 reference(s)