Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Pabpn1tm2.1Gpvl
Name:	poly(A) binding protein, nuclear 1; targeted mutation 2.1, Grace Pavlath
MGI ID:	MGI:5888724
Gene:	Pabpn1  Location: Chr14:55131600-55136384 bp, + strand  Genetic Position: Chr14, 27.98 cM
Alliance:	Pabpn1tm2.1Gpvl page

Germline Transmission:	Earliest citation of germline transmission: J:243638
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 1 and an FRT site flanked puromycin resistance gene cassette and a second loxP site into intron 2. The puro cassette was removed through subsequent Flp-mediated recombination. Exons 1 and 2 were deleted through Cre-mediated recombination, creating a null allele. (J:243638)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pabpn1 Mutation:	12 strains or lines available

Original:	J:243638 Vest KE, et al., Novel mouse models of oculopharyngeal muscular dystrophy (OPMD) reveal early onset mitochondrial defects and suggest loss of PABPN1 may contribute to pathology. Hum Mol Genet. 2017 Sep 01;26(17):3235-3252
All:	1 reference(s)