Tg(tetO-Tgfbr2*)5Twc
Transgene Detail
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| Symbol: |
Tg(tetO-Tgfbr2*)5Twc |
| Name: |
transgene insertion 5, Tony Wyss-Coray |
| MGI ID: |
MGI:5882731 |
| Synonyms: |
tetO-TbetaRIIdeltak |
| Transgene: |
Tg(tetO-Tgfbr2*)5Twc Location: unknown
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| Alliance: |
Tg(tetO-Tgfbr2*)5Twc page
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| Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence) |
| Inducer: |
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doxycycline/tetracycline |
| Mutation: |
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Insertion
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Tg(tetO-Tgfbr2*)5Twc expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| rat |
Tgfbr2 (81810) |
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truncated to delete the transmembrane and intracellular domains |
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Mutation details: The transgenic construct contains a mutated rat transforming growth factor, beta receptor II cDNA driven by the tetracycline operator (tetO). The Tgfbr2 cDNA contains a truncation mutation, resulting in a complete deletion of the transmembrane and intracellular domains.
(J:114572)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:114572 Tesseur I, et al., Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest. 2006 Nov;116(11):3060-9 |
| All: |
3 reference(s) |
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Analysis Tools
