Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Trp63tm1.1Msen
Name:	transformation related protein 63; targeted mutation 1.1, Makoto Senoo
MGI ID:	MGI:5882553
Synonyms:	p63C-
Gene:	Trp63  Location: Chr16:25502513-25710838 bp, + strand  Genetic Position: Chr16, 17.37 cM
Alliance:	Trp63tm1.1Msen page

Germline Transmission:	Earliest citation of germline transmission: J:238904
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: A floxed neomycin resistance cassette replaced exon 12. Cre-mediated recombination removed the selection cassette. This allele leaves only isoform C intact as confirmed by western blot analysis on E14.5 whole epidermal cell extracts. (J:238904)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:	60 strains or lines available

Original:	J:238904 Suzuki D, et al., The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells. Development. 2015 Jan 15;142(2):282-90
All:	1 reference(s)