Tg(TcraMataHari,TcrbMatahari)#Lantz
Transgene Detail
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| Symbol: |
Tg(TcraMataHari,TcrbMatahari)#Lantz |
| Name: |
transgene insertion, Olivier Lantz |
| MGI ID: |
MGI:5829381 |
| Synonyms: |
MataHari, TCR H-Y |
| Transgene: |
Tg(TcraMataHari,TcrbMatahari)#Lantz Location: unknown
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| Alliance: |
Tg(TcraMataHari,TcrbMatahari)#Lantz page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene encodes the alpha and beta chains of a mouse T cell receptor (TCR) specific for the H2-Db-restricted epitope of histocompatibilty Y (HYA, a.k.a. H-Y), WMHHNMDLI, derived from the ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome (Uty). The recombined T cell receptor alpha (Tcra-V15-J16) and beta (Tcrb-V8.3-J1.1) variable region sequences of the MataHari CD8+ T cell clone were inserted into TCRalpha and TCRbeta shuttle vectors, which were then co-injected into fertilized mouse oocytes. The MataHari clone was derived from a B6.A-H2ba H2-T18a/Boy (a.k.a. C57BL/6-Tlaa) female mouse that had been immunized with spleen cells from a male mouse of the same strain.
(J:183981)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:183981 Valujskikh A, et al., Cross-primed CD8(+) T cells mediate graft rejection via a distinct effector pathway. Nat Immunol. 2002 Sep;3(9):844-51 |
| All: |
7 reference(s) |
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Analysis Tools
