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Gene Expression Data
Assay Details
Assay
Reference: J:123097 Mandal MN, et al., CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5505-13
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5828772
Gene symbol: C1qtnf5
Gene name: C1q and tumor necrosis factor related protein 5
Antibody: Anti-Ctrp5 - Ca
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: Two antibodies were described: MGI:5828739 and MGI:5828741. Fig. 5A-C,G specified that MGI:5828739 was used. The remainder of the specimens in this assay could have used either antibody. Authors indicate that both antibodies gave similar results in immunohistochemical analyses.
Results
Specimen not shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: eye mesenchyme Present Regionally restricted Expression was detected in cranial paraxial mesodermal cells that develop into the ciliary body.
Specimen 5A: postnatal day 90 (more )
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present Regionally restricted 5A Expression was detected in a hexagonal lattice on the lateral plasma membranes and the apical processes of the retinal pigmented epithelium.
TS28: retina ganglion cell layer Present 5A
Specimen 5B: postnatal day 90 (more )
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present Regionally restricted 5B Expression was detected in a hexagonal lattice on the lateral plasma membranes and the apical processes of the retinal pigmented epithelium.
Specimen 5C,E: postnatal day 90 (more )
Note: Double labeled: green - C1qtnf5; red - Ezr (assay MGI:5828822).
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present Regionally restricted 5E , 5C Expression was detected in a hexagonal lattice on the lateral plasma membranes and the apical processes of the retinal pigmented epithelium. Expression co-localized with Ezr (Ezrin) on the apical processes.
Specimen 5G: postnatal day 90 (more )
Structure Level Pattern Image Note
TS28: ciliary epithelium Present Punctate 5G Expression was localized to the apposed apical membrane surfaces of the pigmented and nonpigmented cells.
Specimen 5I,J,K: postnatal day 90 (more )
Note: Double labeled: green - C1qtnf5; red - Propidium iodide.
Structure Level Pattern Image Note
TS28: lens epithelium Present Punctate 5I , 5K , 5J Expression was localized to the plasma membrane.
Specimen 6A: postnatal day 90 (more )
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present Punctate 6A A punctate hexagonal pattern membrane localization was noted.
Specimen 6B,D: postnatal day 90 (more )
Note: Double labeled: green - C1qtnf5; red - Tjp1 (assay MGI:5828823).
Structure Level Pattern Image Note
TS28: pigmented retinal epithelium Present Punctate 6B , 6D A punctate hexagonal pattern membrane localization was noted. Expression co-localized with Tjp1.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory