Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Scn5atm1.1Tjh
Name:	sodium channel, voltage-gated, type V, alpha; targeted mutation 1.1, Thomas J Hund
MGI ID:	MGI:5825293
Synonyms:	Scn5a S571E
Gene:	Scn5a  Location: Chr9:119312474-119408082 bp, - strand  Genetic Position: Chr9, 71.33 cM
Alliance:	Scn5atm1.1Tjh page

Germline Transmission:	Earliest citation of germline transmission: J:239053
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Constitutively active) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exon 13 was modified such that an S571E muatation was created in the translated peptide. LoxP sites were inserted in intron 9 and intron 13. An FRT site flanked neomycin resistance gene cassette was inserted between exon 13 and the loxP site. The neo cassette was removed through flp-mediated recombination. The substituted glutamic acid mimics phosphorylated serine. (J:239053)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn5a Mutation:	104 strains or lines available

Original:	J:239053 Glynn P, et al., Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo. Circulation. 2015 Aug 18;132(7):567-77
All:	3 reference(s)