Tg(KRT14-Notch*/ESR1)CA4Fmw
Transgene Detail
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| Symbol: |
Tg(KRT14-Notch*/ESR1)CA4Fmw |
| Name: |
transgene insertion CA4, Fiona M Watt |
| MGI ID: |
MGI:5824128 |
| Synonyms: |
K14NICDdeltaOPER, K14NICDER, line 5199.21A,B+C, line CA4 |
| Transgene: |
Tg(KRT14-Notch*/ESR1)CA4Fmw Location: unknown
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| Alliance: |
Tg(KRT14-Notch*/ESR1)CA4Fmw page
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| Transgene Type: |
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Transgenic (Constitutively active, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(KRT14-Notch*/ESR1)CA4Fmw expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Notch1 (MGI:97363) |
expresses amino acids 1751-2290 of the intracellular domain |
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Mutation details: The transgene consists of a construct that expresses amino acids 1751-2290 of the mouse Notch1 intracellular domain (NICDOP) with an N-terminal FLAG sequence and a modified estrogen receptor (ER) fused in frame at the C terminus. Expression of the construct is driven by a keratin 14 promoter cassette. Founder lines 5199.15A,B+C (CA3, low copy number) and 5199.21A,B+C (CA4, contains 21 copies of the transgene at high copy number) were established; both lines had a similar phenotype, the severity correlating with copy number. Line CA4 was studied further.
(J:115280, J:142873)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:115280 Estrach S, et al., Jagged 1 is a {beta}-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development. 2006 Nov;133(22):4427-38 |
| All: |
4 reference(s) |
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Analysis Tools
