Tg(SV40-Nfkb*-lacZ)17814Pabk
Transgene Detail
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| Symbol: |
Tg(SV40-Nfkb*-lacZ)17814Pabk |
| Name: |
transgene insertion 17814, PA Barker |
| MGI ID: |
MGI:5824089 |
| Synonyms: |
NF-kBLacZ, NF-kBREP |
| Transgene: |
Tg(SV40-Nfkb*-lacZ)17814Pabk Location: unknown
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| Alliance: |
Tg(SV40-Nfkb*-lacZ)17814Pabk page
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| Strain of Origin: |
C3H x BALB/c
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| Transgene Type: |
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Transgenic (Reporter) |
| Mutation: |
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Insertion
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Mutation details: An NF-kappaB responsive minigene containing three tandem HIV-derived kappaB binding element repeats was placed proximal to a minimal promoter derived from SV40. Upon NF-kappaB binding, this construct drives expression of beta-galactosidase that was modified to include an SV40 T-antigen-derived nuclear localization sequence. 10 founder lines were generated, and three founder lines (17814, 17815, and 17819) were kept and studied further.
(J:79207)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:79207 Bhakar AL, et al., Constitutive nuclear factor-kappa B activity is required for central neuron survival. J Neurosci. 2002 Oct 1;22(19):8466-75 |
| All: |
15 reference(s) |
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Analysis Tools
