Tg(TAGLN-NOTCH3*R90C)1Etl
Transgene Detail
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| Symbol: |
Tg(TAGLN-NOTCH3*R90C)1Etl |
| Name: |
transgene insertion 1, Elisabeth Tournier-Lasserve |
| MGI ID: |
MGI:5823251 |
| Synonyms: |
line Ma, TghN3(R90C), TgMa, TgNotch3R90C, transgenic mauve |
| Transgene: |
Tg(TAGLN-NOTCH3*R90C)1Etl Location: unknown
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| Alliance: |
Tg(TAGLN-NOTCH3*R90C)1Etl page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(TAGLN-NOTCH3*R90C)1Etl expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
NOTCH3 (4854) |
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contains an R90C substitution |
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Mutation details: A 7021-bp full-length human Notch3 cDNA carrying the codon 90 CGT to TGT mutation was ligated to a 2191-bp fragment of the TAGLN gene promoter, including 2126 bp upstream of the initiation transcription site and the complete noncoding first exon. A 584 bp fragment of the bovine beta-globin intron was inserted between the SM22alpha regulatory sequence and the Notch3 sequence. A polyadenylation signal was derived from the SV40 poly(A) DNA and was inserted at the 3 end of the construct. Three lines were generated; lines Ma (1, mauve) and Ve (2, verte) were used for further analysis.
(J:129831)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:129831 Ruchoux MM, et al., Transgenic mice expressing mutant Notch3 develop vascular alterations characteristic of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Am J Pathol. 2003 Jan;162(1):329-42 |
| All: |
5 reference(s) |
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Analysis Tools
