Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Htr2ctm1(cre)Heis
Name:	5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1, Lora Heisler
MGI ID:	MGI:5819072
Gene:	Htr2c  Location: ChrX:145745509-145980273 bp, + strand  Genetic Position: ChrX, 68.46 cM, cytoband D-F4
Alliance:	Htr2ctm1(cre)Heis page

Germline Transmission:	Earliest citation of germline transmission: J:238329
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Htr2ctm1(cre)Heis expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Htr2c (MGI:96281)   Mutation details: The targeting construct was generated by insertion of a FRT-NEO-FRT-IRES-CRE cassette between the stop codon and the polyA site of the gene. (J:238329)

Activity:	Tissue activity of this recombinase allele
Driver:	Htr2c (mouse) Summary of all recombinase alleles driven by Htr2c. Alliance mouse Htr2c gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htr2c Mutation:	12 strains or lines available

Original:	J:238329 Burke LK, et al., Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Mol Metab. 2016 Mar;5(3):245-52
All:	1 reference(s)