Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Trpv4em1(cre/ERT2)Amc
Name:	transient receptor potential cation channel, subfamily V, member 4; endonuclease-mediated mutation 1, Andrew P McMahon
MGI ID:	MGI:5818185
Synonyms:	Trpv4 CE
Gene:	Trpv4  Location: Chr5:114760213-114796482 bp, - strand  Genetic Position: Chr5, 55.99 cM, cytoband F
Alliance:	Trpv4em1(cre/ERT2)Amc page

Germline Transmission:	Earliest citation of germline transmission: J:159099
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Endonuclease-mediated (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Trpv4em1(cre/ERT2)Amc expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Trpv4 (MGI:1926945)   Mutation details: Plasmids encoding a signal guide RNA designed to introduce a cre/ERT2 knock-in mutation into exon 2 of the Trpv4 gene and the cas9 nuclease were introduced into the cytoplasm of C57BL/6N-derived JM8.N4 ES cells. (J:159099)

Activity:	Tissue activity of this recombinase allele
Driver:	Trpv4 (mouse) Summary of all recombinase alleles driven by Trpv4. Comparative matrix view of recombinase activities Alliance mouse Trpv4 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpv4 Mutation:	57 strains or lines available

Original:	J:159099 McMahon A, et al., Summary of mouse strains characterized by GUDMAP consortium. Unpublished. 2010;
All:	1 reference(s)