Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Tcra,Tcrb)6482Dmky
Name:	transgene insertion 6482, David M Kemeny
MGI ID:	MGI:5816373
Synonyms:	BT-II
Transgene:	Tg(Tcra,Tcrb)6482Dmky  Location: unknown
Alliance:	Tg(Tcra,Tcrb)6482Dmky page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(Tcra,Tcrb)6482Dmky expresses 2 genes Transgene expresses: Organism Expressed Gene Note mouse Tcra (MGI:98553) mouse Tcrb (MGI:98578)   Mutation details: Rearranged Blo t 5 peptide 55-70 (from the storage mite Blomia tropicalis) specific T cell ValphaJalpha and VbetaD&betaJbeta genes were cloned into pTalpha and pTbeta cassettes. Transgenic constructs generated from these cassette vectors, contain the alpha-chain and beta-chain of the T-cell receptor from a T cell hybridoma clone> (J:237613)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:237613 Chua YL, et al., Blomia tropicalis-Specific TCR Transgenic Th2 Cells Induce Inducible BALT and Severe Asthma in Mice by an IL-4/IL-13-Dependent Mechanism. J Immunol. 2016 Nov 15;197(10):3771-3781
All:	1 reference(s)