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Gene Expression Data
Assay Details
Assay
Reference: J:195918 Vieux-Rochas M, et al., BMP-mediated functional cooperation between Dlx5;Dlx6 and Msx1;Msx2 during mammalian limb development. PLoS One. 2013;8(1):e51700
Assay type: RNA in situ
MGI Accession ID: MGI:5810613
Gene symbol: Grem1
Gene name: gremlin 1, DAN family BMP antagonist
Probe: Gremlin probe2
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 4G: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: forelimb bud Present 4G
Specimen 4H: embryonic day 11.0; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi (more )
Note: This embryo was a single homozygote. However, since this allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS18: forelimb bud Present 4H Expression unchanged compared with wildtype.
Specimen 4I: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: hindlimb bud Present 4I
Specimen 4J: embryonic day 11.0; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi (more )
Note: This embryo was a single homozygote. However, since this allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS18: hindlimb bud Present 4J Expression unchanged compared with wildtype.
Specimen 4K: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: hindlimb bud Present 4K
Specimen 4L: embryonic day 11.0; Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi, Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi (more )
Note: This embryo was a single homozygote. However, since this allele affects two genes, the MGI database schema requires that we need to enter an allele pair per affected gene (thus resulting in the animal looking like a double homozygote).
Structure Level Pattern Image Note
TS18: hindlimb bud Present 4L Expression unchanged compared with wildtype.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory