Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Liastm2.1Mae
Name:	lipoic acid synthetase; targeted mutation 2.1, Nobuyo Maeda
MGI ID:	MGI:5810126
Synonyms:	LiasLow
Gene:	Lias  Location: Chr5:65548840-65567766 bp, + strand  Genetic Position: Chr5, 33.66 cM, cytoband C3.3
Alliance:	Liastm2.1Mae page

Germline Transmission:	Earliest citation of germline transmission: J:236908
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: The targeting vector consists of a loxP site, the 3' UTR sequence of the bovine growth hormone gene, a neomycin cassette and a loxP site followed by the 3'-UTR sequence of the cFos gene. Cre-mediated recombination removed the bovine growth hormone gene and neo cassette, allowing cFos to drive expression of the endogenous gene. Expression is 25% of the endogenous gene expression. (J:236908)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lias Mutation:	25 strains or lines available

Original:	J:236908 Xu L, et al., Influence of Different Levels of Lipoic Acid Synthase Gene Expression on Diabetic Nephropathy. PLoS One. 2016;11(10):e0163208
All:	1 reference(s)