Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Pdgfrb-cre/ERT2)6096Rha
Name:	transgene insertion 6096, Ralf H Adams
MGI ID:	MGI:5807436
Synonyms:	Pdgfrb(BAC)-CreERT2, PDGFR-betaiCre
Transgene:	Tg(Pdgfrb-cre/ERT2)6096Rha  Location: Chr5:56455226-56491644 bp  Genetic Position: Chr5, Syntenic
Alliance:	Tg(Pdgfrb-cre/ERT2)6096Rha page

Strain of Origin:

(C57BL/6 x 129)F1

Transgene Type:    Transgenic (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tg(Pdgfrb-cre/ERT2)6096Rha expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Pdgfrb (MGI:97531)   Mutation details: Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a BAC (#RP24-62H17TJ) containing the entire murine platelet-derived growth factor receptor, beta polypeptide (Pdgfrb) gene. This BAC was modified to insert a creER fusion gene (a cre recombinase fused to a human estrogen receptor ligand-binding domain) into the start codon of Pdgfrb to drive expression in mural cells. The other genes on the BAC (Camk2a, Slc6a7, Cdx1, Csf1r, and Hmgxb3) are still present in the construct. (J:236848)

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfrb (mouse) Summary of all recombinase alleles driven by Pdgfrb. Comparative matrix view of recombinase activities Alliance mouse Pdgfrb gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:236849 Gerl K, et al., Inducible glomerular erythropoietin production in the adult kidney. Kidney Int. 2015 Dec;88(6):1345-1355
All:	25 reference(s)