Tg(Pdgfrb-cre/ERT2)6096Rha
Transgene Detail
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Symbol: |
Tg(Pdgfrb-cre/ERT2)6096Rha |
Name: |
transgene insertion 6096, Ralf H Adams |
MGI ID: |
MGI:5807436 |
Synonyms: |
Pdgfrb(BAC)-CreERT2, PDGFR-betaiCre |
Transgene: |
Tg(Pdgfrb-cre/ERT2)6096Rha Location: Chr5:56455226-56491644 bp Genetic Position: Chr5, Syntenic
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Alliance: |
Tg(Pdgfrb-cre/ERT2)6096Rha page
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Transgene Type: |
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Transgenic (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Tg(Pdgfrb-cre/ERT2)6096Rha expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Pdgfrb (MGI:97531) |
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Mutation details: Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a BAC (#RP24-62H17TJ) containing the entire murine platelet-derived growth factor receptor, beta polypeptide (Pdgfrb) gene. This BAC was modified to insert a creER fusion gene (a cre recombinase fused to a human estrogen receptor ligand-binding domain) into the start codon of Pdgfrb to drive expression in mural cells. The other genes on the BAC (Camk2a, Slc6a7, Cdx1, Csf1r, and Hmgxb3) are still present in the construct.
(J:236848)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Pdgfrb
(mouse)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:236849 Gerl K, et al., Inducible glomerular erythropoietin production in the adult kidney. Kidney Int. 2015 Dec;88(6):1345-1355 |
All: |
25 reference(s) |
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