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Gene Expression Data
Assay Details
Assay
Reference: J:59282 Yi SE, et al., The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development. 2000 Feb;127(3):621-30
Assay type: RNA in situ
MGI Accession ID: MGI:5806796
Gene symbol: Gdf5
Gene name: growth differentiation factor 5
Probe: Gdf5 cDNA7
Probe preparation: Antisense RNA
Results
Specimen 3c Wild type: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: hand Present Regionally restricted 3c wild type Expression was detected in regions of future joint formation.
Specimen 3c BmprIB-/-: embryonic day 12.0; Bmpr1btm1Kml/Bmpr1btm1Kml (more )
Structure Level Pattern Image Note
TS20: hand Present Regionally restricted 3c BmprIB-/- No difference was detected in the expression pattern in the mutant.
Specimen 3d Wild type: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: forelimb digit Present 3d wild type Expression was detected in the digital ray.
Specimen 3d BmprIB-/-: embryonic day 13.0; Bmpr1btm1Kml/Bmpr1btm1Kml (more )
Structure Level Pattern Image Note
TS21: forelimb digit Present 3d BmprIB-/- Expression in the digital ray was expanded in the mutant relative to the wild type pattern.
Specimen 3e Wild type: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: hand joint Present Regionally restricted 3e wild type Expression was restricted to the presumptive joint interzone and the cells that will form the synovial capsules.
TS21: forelimb interphalangeal joint Present Regionally restricted 3e wild type Expression was detected in the future synovial capsule of the interphalangeal joint.
Specimen 3e BmprIB-/-: embryonic day 13.5; Bmpr1btm1Kml/Bmpr1btm1Kml (more )
Structure Level Pattern Image Note
TS21: forelimb digit Present Regionally restricted 3e BmprIB-/- In the mutant, a single elongated domain of expression was observed in the region of the digital ray corresponding to the proximal and middle phalanges.
TS21: forelimb interphalangeal joint Weak Regionally restricted 3e BmprIB-/- Expression in the future synovial capsule of the interphalangeal joint is greatly reduced in the mutant.
Specimen 4c: embryonic day 13.5; Bmpr1btm1Kml/Bmpr1btm1Kml (more )
Structure Level Pattern Image Note
TS21: forelimb digit Present Regionally restricted 4c Expression was detected in the phalangeal region.
Specimen 4g Wild type: embryonic day 13.5 (more )
Note: Also labeled for BrdU.
Structure Level Pattern Image Note
TS21: forelimb digit Present Regionally restricted 4g wild type Expression was detected in the phalangeal region.
Specimen 4g BmprIB-/-: embryonic day 13.5; Bmpr1btm1Kml/Bmpr1btm1Kml (more )
Note: Also labeled for BrdU.
Structure Level Pattern Image Note
TS21: forelimb digit Present Regionally restricted 4g BmprIB-/- Expression was detected in the phalangeal region.
Specimen 5a,c: embryonic day 12.5 (more )
Note: Overlay of adjacent sections; green - Gdf; purple - Bmpr1b.
Structure Level Pattern Image Note
TS20: limb Present Regionally restricted 5c , 5a Gdf5 and Bmpr1b are expressed in nonoverlapping, but adjacent regions of the limb.
Specimen 5d,f: embryonic day 13.5 (more )
Note: Overlay of adjacent sections; green - Gdf; purple - Bmpr1b.
Structure Level Pattern Image Note
TS21: limb Present Regionally restricted 5d , 5f Gdf5 and Bmpr1b are expressed in nonoverlapping, but adjacent regions of the limb.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory