Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Adartm1.1Xen
Name:	adenosine deaminase, RNA-specific; targeted mutation 1.1, Taconic Biosciences
MGI ID:	MGI:5805648
Synonyms:	Adar1E861A
Gene:	Adar  Location: Chr3:89622329-89660753 bp, + strand  Genetic Position: Chr3, 39.19 cM, cytoband F2
Alliance:	Adartm1.1Xen page

Germline Transmission:	Earliest citation of germline transmission: J:226177
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: An F3 site flanked puromycin resistance cassette was inserted upstream of exon 7. Exon 9 was replaced with a modified one in which nucleotide substitutions (GAA to GCT) that result in the amino acid substitution of glutamic acid with alanine at position 861 (p.E861A). This mutation is predicted to produce a catalyticly inactivated protein. Flp-mediated recombination removed the selection cassette. (J:226177)

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adar Mutation:	71 strains or lines available

Original:	J:226177 Liddicoat BJ, et al., RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself. Science. 2015 Sep 4;349(6252):1115-20
All:	8 reference(s)