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Tg(Nos1-COP4*H134R/YFP)3Gjau
Transgene Detail
Summary
Symbol: Tg(Nos1-COP4*H134R/YFP)3Gjau
Name: transgene insertion 3, George Augustine
MGI ID: MGI:5805549
Synonyms: nNOS-hChR2(H134R)-YFP
Transgene: Tg(Nos1-COP4*H134R/YFP)3Gjau  Location: unknown  
Alliance: Tg(Nos1-COP4*H134R/YFP)3Gjau page
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsThe trangene cassette was generated by inserting the reporter cassette downstream of the translation initiation sequence in BAC RP24-164C18. The mouse promoter drives molecular layer interneuron-specific expression of the mammalian codon-optimized Chlamydomonas reinhardtii-derived channel rhodopsin-2 that was modified to harbor a gain-of-function H134R substitution (hChR2-H134R) fused in-frame with a yellow fluorescent protein (YFP) and followed by a bovin growth hormon 3'UTR. Line 3 was generated. (J:236224)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:236224 Kim J, et al., Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses. Cell Rep. 2014 Jun 12;7(5):1601-13
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/06/2026
MGI 6.24
The Jackson Laboratory