Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Col1a2-KLF6*)1Fdmn
Name:	transgene insertion 1, Scott Friedman
MGI ID:	MGI:5796480
Synonyms:	Colalpha2(I)-KLF6-SV1
Transgene:	Tg(Col1a2-KLF6*)1Fdmn  Location: unknown
Alliance:	Tg(Col1a2-KLF6*)1Fdmn page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Col1a2-KLF6*)1Fdmn expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human KLF6 (1316) Klf6  (MGI:1346318) splice variant 1   Mutation details: The transgene was designed with a mutant human KLF6 gene driven by the collagen, type I, alpha 2 (Col1a2) promoter. The KLF6 alternative splice isoform - splice variant 1 (SV1) - lacks the DNA binding domain. (J:235492)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:235492 Ghiassi-Nejad Z, et al., Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury. Hepatology. 2013 Feb;57(2):786-96
All:	1 reference(s)