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Gene Expression Data
Assay Details
Assay
Reference: J:123565 Hayakawa-Yano Y, et al., Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord. Stem Cells. 2007 Jun;25(6):1410-22
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5795657
Gene symbol: Olig2
Gene name: oligodendrocyte transcription factor 2
Antibody: anti-Olig2
Detection system: Secondary antibody
Results
Specimen 1I: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted 1I Expression is in the motor neuron progenitor domain.
Specimen 1M: embryonic day 12.5; Gab1tm1Thir/Gab1tm1Thir (more )
Structure Level Pattern Image Note
TS20: spinal cord Weak Regionally restricted 1M Expression in the motor neuron progenitor domain is about 43% of wild-type.
Specimen 2D E12.5: embryonic day 12.5 (more )
Note: Double labeled: green - Olig2; red - Egfr (assay MGI:5795683).
Structure Level Pattern Image Note
TS20: spinal cord Present Regionally restricted 2D E12.5 left , 2D E12.5 right Expression is in the motor neuron progenitor domain.
Specimen 2D E13.5: embryonic day 13.5 (more )
Note: Double labeled: green - Olig2; red - Egfr (assay MGI:5795683).
Structure Level Pattern Image Note
TS21: spinal cord Present Regionally restricted 2D E13.5 left , 2D E13.5 right Expression is in the motor neuron progenitor domain.
Specimen 2D E14.5: embryonic day 14.5 (more )
Note: Double labeled: green - Olig2; red - Egfr (assay MGI:5795683).
Structure Level Pattern Image Note
TS22: spinal cord Present Regionally restricted 2D E14.5 left , 2E 14.5 right Expression is in the motor neuron progenitor domain.
Specimen 3A: embryonic day 13.5 (more )
Note: Double labeled: green - Olig2; red - phospho-Histone3.
Structure Level Pattern Image Note
TS21: spinal cord ventricular layer Present Regionally restricted 3A Expression is in the motor neuron progenitor domain.
Specimen 3B: embryonic day 13.5 (more )
Note: Double labeled: green - Olig2; red - Nkx2-2 (assay MGI:5795678).
Structure Level Pattern Image Note
TS21: spinal cord marginal layer Present Regionally restricted 3B Expression is in oligodendrocyte progenitor cells.
TS21: spinal cord ventricular layer Present Regionally restricted 3B Expression is in oligodendrocyte progenitor cells.
Specimen 3C: embryonic day 14.5 (more )
Note: Double labeled: green - Olig2; red - Nkx2-2 (assay MGI:5795678).
Structure Level Pattern Image Note
TS22: spinal cord marginal layer Present Regionally restricted 3C Expression is ventral.
TS22: spinal cord ventricular layer Present Regionally restricted 3C Expression is ventral.
Specimen 3D: embryonic day 14.5 (more )
Note: Double labeled: green - Olig2; red - Pax7 (assay MGI:5795641).
Structure Level Pattern Image Note
TS22: spinal cord Present Single cells 3D Expression is in cells in the dorsal spinal cord.
Specimen 3E: embryonic day 14.5 (more )
Note: Double labeled: green - Olig2; red - Egfr (assay MGI:5795683).
Structure Level Pattern Image Note
TS22: spinal cord Present Single cells 3E Expression is in cells in the dorsal spinal cord.
Specimen 3G: embryonic day 13.5; Gab1tm1Thir/Gab1tm1Thir (more )
Note: Double labeled: green - Olig2; red - phospho-Histone3.
Structure Level Pattern Image Note
TS21: spinal cord ventricular layer Weak Regionally restricted 3G The number of expressing cells in the motor neuron progenitor domain is reduced in this mutant.
Specimen 3H: embryonic day 13.5; Gab1tm1Thir/Gab1tm1Thir (more )
Note: Double labeled: green - Olig2; red - Nkx2-2 (assay MGI:5795678).
Structure Level Pattern Image Note
TS21: spinal cord marginal layer Weak Regionally restricted 3H The number of expressing oligodendrocyte progenitor cells is reduced in this mutant.
TS21: spinal cord ventricular layer Weak Regionally restricted 3H The number of expressing oligodendrocyte progenitor cells is reduced in this mutant.
Specimen 3I: embryonic day 14.5; Gab1tm1Thir/Gab1tm1Thir (more )
Note: Double labeled: green - Olig2; red - Nkx2-2 (assay MGI:5795678).
Structure Level Pattern Image Note
TS22: spinal cord ventricular layer Present Regionally restricted 3I Expression in the ventral ventricular zone is the same as in wild-type embryos.
TS22: spinal cord marginal layer Weak Regionally restricted 3I The number of expressing cells in the ventral marginal zone is reduced in this mutant.
Specimen 3J: embryonic day 14.5; Gab1tm1Thir/Gab1tm1Thir (more )
Note: Double labeled: green - Olig2; red - Pax7 (assay MGI:5795641).
Structure Level Pattern Image Note
TS22: spinal cord Present Single cells 3J Expression in cells in the dorsal spinal cord is the same as in wild-type embryos.
Specimen 3K: embryonic day 14.5; Gab1tm1Thir/Gab1tm1Thir (more )
Note: Double labeled: green - Olig2; red - Egfr (assay MGI:5795683).
Structure Level Pattern Image Note
TS22: spinal cord Present Single cells 3K Expression in cells in the dorsal spinal cord is the same as in wild-type embryos.
Specimen 4A: embryonic day 13.5 (more )
Note: Double labeled: green - Olig2; red - phospho-Histone3.
Structure Level Pattern Image Note
TS21: spinal cord marginal layer Present Single cells 4A
TS21: spinal cord ventricular layer Present Single cells 4A
Specimen 4B: embryonic day 13.5; Egfrtm1Mag/Egfrtm1Mag (more )
Note: Double labeled: green - Olig2; red - phospho-Histone3.
Structure Level Pattern Image Note
TS21: spinal cord marginal layer Present Single cells 4B The number of expressing cells is reduced in this mutant.
TS21: spinal cord ventricular layer Present Single cells 4B The number of expressing cells is reduced in this mutant.
Specimen 4E: embryonic day 13.5 (more )
Note: Double labeled: green - Olig2; red - Nkx2-2 (assay MGI:5795678).
Structure Level Pattern Image Note
TS21: spinal cord marginal layer Present Single cells 4E Expression is ventral.
TS21: spinal cord ventricular layer Present Single cells 4E Expression is ventral.
Specimen 4F: embryonic day 13.5; Egfrtm1Mag/Egfrtm1Mag (more )
Note: Double labeled: green - Olig2; red - Nkx2-2 (assay MGI:5795678).
Structure Level Pattern Image Note
TS21: spinal cord marginal layer Present Single cells 4F The number of expressing cells is reduced in this mutant.
TS21: spinal cord ventricular layer Present Single cells 4F The number of expressing cells is reduced in this mutant.
Specimen 4I: embryonic day 14.5 (more )
Note: Double labeled: green - Olig2; red - Nkx2-2 (assay MGI:5795678).
Structure Level Pattern Image Note
TS22: spinal cord marginal layer Present Single cells 4I Expression is ventral.
TS22: spinal cord ventricular layer Present Single cells 4I Expression is ventral.
Specimen 4J: embryonic day 14.5; Egfrtm1Mag/Egfrtm1Mag (more )
Note: Double labeled: green - Olig2; red - Nkx2-2 (assay MGI:5795678).
Structure Level Pattern Image Note
TS22: spinal cord ventricular layer Present Single cells 4J Expression is ventral and is the same as wild-type.
TS22: spinal cord marginal layer Present Single cells 4J The number of expressing cells is reduced in this mutant.
Specimen 4M: embryonic day 14.5 (more )
Note: Double labeled: green - Olig2; red - Pax7 (assay MGI:5795641).
Structure Level Pattern Image Note
TS22: spinal cord Present Regionally restricted 4M Expression is dorsal.
Specimen 4N: embryonic day 14.5; Egfrtm1Mag/Egfrtm1Mag (more )
Note: Double labeled: green - Olig2; red - Pax7 (assay MGI:5795641).
Structure Level Pattern Image Note
TS22: spinal cord Present 4N Expression is reduced in this mutant.
Specimen S1 C: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: neural tube Present S1C
Specimen S1 H: embryonic day 11.0; Gab1tm1Thir/Gab1tm1Thir (more )
Structure Level Pattern Image Note
TS18: neural tube Present S1H Expression in this mutant is the same as in wild-type.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory