Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Calb1tm2.1(cre)Hze
Name:	calbindin 1; targeted mutation 2.1, Hongkui Zeng
MGI ID:	MGI:5792816
Synonyms:	Calb1-IRES2-Cre-D, CBCre
Gene:	Calb1  Location: Chr4:15881264-15906709 bp, + strand  Genetic Position: Chr4, 6.66 cM
Alliance:	Calb1tm2.1(cre)Hze page

Germline Transmission:	Earliest citation of germline transmission: J:146821
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Calb1tm2.1(cre)Hze expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Calb1 (MGI:88248)   Mutation details: The targeting vector contains, from 5' to 3', an FRT3 site within Calb1 intron 10, a partial Calb1 exon 11 sequence up to and including the endogenous stop codon,an IRES2 sequence, Cre recombinase, a polyA sequence, an AttB site, a PGK-Neomycin cassette, an FRT5 site, an mRNA splice acceptor sequence, the 3' portion of the hygromycin gene (Hygro2) with SV40 late polyA signal, and an AttP site. PhiC31-mediated recombination removed the AttB/AttP-flanked sequence (PGK-Neo-polyA::FRT5::RNA splice acceptor::3'hygro-polyA) and replaced it with the recombined AttB/AttP site (AttL). Mice have both endogenous gene and Cre recombinase expression directed to calbindin 1-expressing cells by the endogenous promoter/enhancer elements of the Calb1 locus. (J:146821)

Activity:	Tissue activity of this recombinase allele
Driver:	Calb1 (mouse) Summary of all recombinase alleles driven by Calb1. Comparative matrix view of recombinase activities Alliance mouse Calb1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Calb1 Mutation:	27 strains or lines available

Original:	J:146821 Allen Institute for Brain Science, Cre transgenes and knockin alleles created at the Allen Insitute for Brain Science (AIBS). MGI Direct Data Submission. 2009-04-06;
All:	22 reference(s)