Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(tetO/Prnp-TARDBP*)2Vle
Name:	transgene insertion 2, Virginia M Y Lee
MGI ID:	MGI:5792270
Synonyms:	tetO-208 TDP-43 Tg
Transgene:	Tg(tetO/Prnp-TARDBP*)2Vle  Location: unknown
Alliance:	Tg(tetO/Prnp-TARDBP*)2Vle page

Strain of Origin:

(C57BL/6J x C3H/HeJ)F1

Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO/Prnp-TARDBP*)2Vle expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human TARDBP (23435) Tardbp  (MGI:2387629) expression of amino acids 208-414 from human TARDBP   Mutation details: The transgenic construct contains the Tet-responsive element and mouse prion protein non-coding exons 1-2 upstream of a cDNA sequence encoding amino acids 208-414 of human TAR DNA binding protein (TARDBP or TDP-43) followed by the mouse prion protein non-coding exon 3 and 3' UTR of the moPrP.XhoI vector (including polyadenylation signal). Three founder lines were generated. Founder line 2 had the highest inducible expression of 208 TDP-43 C-terminal fragments (CTFs), and all three lines have the same inducible 208 TDP-43 CTF distribution and biochemical properties. (J:226974)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:226974 Walker AK, et al., An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Hum Mol Genet. 2015 Dec 20;24(25):7241-54
All:	2 reference(s)