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Gene Expression Data
Assay Details
Assay
Reference: J:133682 Jones NC, et al., Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function. Nat Med. 2008 Feb;14(2):125-33
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5792131
Gene symbol: Casp3
Gene name: caspase 3
Antibody: anti-caspase3 (3G2) (#9668)
Detection system: Secondary antibody
Assay notes: The antibody recognizes the activated form of the protein.
Results
Specimen 4a: embryonic day 9.0-9.5 (more )
Structure Level Pattern Image Note
TS15: neural tube Trace 4a

Specimen 4b: embryonic day 9.0-9.5; Tcof1tm1Mjd/Tcof1+ (more )
Structure Level Pattern Image Note
TS15: neural tube Present 4b

Specimen 4c: embryonic day 9.0-9.5; Tcof1tm1Mjd/Tcof1+, Trp53tm1Brd/Trp53+ (more )
Structure Level Pattern Image Note
TS15: neural tube Weak 4c

Specimen S1a: embryonic day 9.0; Tcof1tm1Mjd/Tcof1+, Trp53tm1Brd/Trp53+ (more )
Structure Level Pattern Image Note
TS14: neural tube Weak S1a

Specimen S1b: embryonic day 9.0; Tcof1tm1Mjd/Tcof1+, Trp53tm1Brd/Trp53tm1Brd (more )
Structure Level Pattern Image Note
TS14: neural tube Trace S1b

Specimen S1c Tcof1+/+: embryonic day 9.0 (more )
Note: Quantification of positive cell numbers are shown in a table.
Structure Level Pattern Image Note
TS14: neural tube Trace S1c Tcof1+/+

Specimen S1c Tcof1+/-: embryonic day 9.0; Tcof1tm1Mjd/Tcof1+ (more )
Note: Quantification of positive cell numbers are shown in a table.
Structure Level Pattern Image Note
TS14: neural tube Present S1c Tcof1+/-

Specimen S1c Tcof1+/-;p53+/-: embryonic day 9.0; Tcof1tm1Mjd/Tcof1+, Trp53tm1Brd/Trp53+ (more )
Note: Quantification of positive cell numbers are shown in a table.
Structure Level Pattern Image Note
TS14: neural tube Weak S1c Tcof1+/-;p53+/-

Specimen S1c Tcof1+/-;p53-/-: embryonic day 9.0; Tcof1tm1Mjd/Tcof1+, Trp53tm1Brd/Trp53tm1Brd (more )
Note: Quantification of positive cell numbers are shown in a table.
Structure Level Pattern Image Note
TS14: neural tube Trace S1c Tcof1+/-;p53-/-


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/24/2026
MGI 6.24
The Jackson Laboratory