Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Foxp3-HBEGF/EGFP)1Doi
Name:	transgene insertion 1, Christophe Benoist
MGI ID:	MGI:5789576
Synonyms:	Foxp3DTR, Foxp3-DTR
Transgene:	Tg(Foxp3-HBEGF/EGFP)1Doi  Location: unknown
Alliance:	Tg(Foxp3-HBEGF/EGFP)1Doi page

Strain of Origin:

NOD/ShiLtJ

Transgene Type:    Transgenic (Inserted expressed sequence, Reporter) Mutation:    Insertion   Tg(Foxp3-HBEGF/EGFP)1Doi expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human HBEGF (1839) Hbegf  (MGI:96070) fused to EGFP   Mutation details: A BAC containing Foxp3 was modified by inserting a human heparin-binding EGF-like growth factor (HBEGF or DTR, diptheria toxin receptor) sequence fused to an enhanced green fluorescent protein (EGFP) with a stop codon between the first and second codons of the Foxp3 open reading frame. (J:153752)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:153752 Feuerer M, et al., How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity. 2009 Oct 16;31(4):654-64
All:	7 reference(s)