Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ip6k3tm1.1Snyd
Name:	inositol hexaphosphate kinase 3; targeted mutation 1.1, Solomon Snyder
MGI ID:	MGI:5788648
Gene:	Ip6k3  Location: Chr17:27362945-27386738 bp, - strand  Genetic Position: Chr17, 13.77 cM
Alliance:	Ip6k3tm1.1Snyd page

Germline Transmission:	Earliest citation of germline transmission: J:225876
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele is an cre/loxP-induced intragenic deletion of the splice site, coding region, and the 3'UTR of exon 6. Immunostaining revealed substantial levels in cortex, hippocampus, thalamus, hypothalamus, and cerebellum with virtually total loss of the enzyme in homozygous mutant mice. (J:225876)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ip6k3 Mutation:	21 strains or lines available

Original:	J:225876 Fu C, et al., Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin. J Neurosci. 2015 Aug 5;35(31):11056-67
All:	3 reference(s)