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Gene Expression Data
Assay Details
Assay
Reference: J:133600 Aoki M, et al., R-spondin2 expression in the apical ectodermal ridge is essential for outgrowth and patterning in mouse limb development. Dev Growth Differ. 2008 Feb;50(2):85-95
Assay type: RNA in situ
MGI Accession ID: MGI:5788477
Gene symbol: Fgf4
Gene name: fibroblast growth factor 4
Probe: Fgf4 probe29
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 4E: embryonic day 10.5; Rspo2tm1Hoka/Rspo2tm1Hoka (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present Regionally restricted 4E Expression shifted to a more anterior position compared to wildtype limbs in 4 of 6 mutant forelimbs analyzed.
Specimen 4F: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: forelimb bud apical ectodermal ridge Present Regionally restricted 4F Expression in the posterior region of the AER.
Specimen 4M: embryonic day 10.5; Rspo2tm1Hoka/Rspo2tm1Hoka (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present Regionally restricted 4M Lower level of expression compared to the wildtype hindlimbs
Specimen 4N: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Ambiguous 4N Authors state expression almost absent in 3 out of 6 mutant hindlimbs.
Specimen 4O: embryonic day 10.5; Rspo2tm1Hoka/Rspo2tm1Hoka (more )
Structure Level Pattern Image Note
TS17: hindlimb bud apical ectodermal ridge Present Regionally restricted 4O Expression in the posterior region of the AER.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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01/28/2026
MGI 6.24 		The Jackson Laboratory