Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppp3r2em1Osb
Name:	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II); endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI ID:	MGI:5788176
Gene:	Ppp3r2  Location: Chr4:49678747-49681983 bp, - strand  Genetic Position: Chr4, 26.75 cM, cytoband B3
Alliance:	Ppp3r2em1Osb page

Strain of Origin:

(C57BL/6NJcl x DBA/2NJcl)F2

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: CRISPR/Cas9 technology targeting exon 1 deleted 372 bp of sequence. Western blot analysis confrimed the absence of protein expression in the testis and sperm. (J:226539)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ppp3r2 Mutation:	14 strains or lines available

Original:	J:226539 Miyata H, et al., Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive. Science. 2015 Oct 23;350(6259):442-5
All:	1 reference(s)