Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(tetO-MAPT*A152T)L1Lms
Name:	transgene insertion L1, Lennart Mucke
MGI ID:	MGI:5788163
Synonyms:	hTau-A152T, TRE-hTau-A152T
Transgene:	Tg(tetO-MAPT*A152T)L1Lms  Location: unknown
Alliance:	Tg(tetO-MAPT*A152T)L1Lms page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Tg(tetO-MAPT*A152T)L1Lms expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human MAPT (4137) Mapt  (MGI:97180) with mutation A152T   Mutation details: A transgenic construct containing cDNA of the human MAPT gene encoding the 1N4R isoform, with upstream intronic sequence (from pCI-neo vector) and a Kozak sequence, and downstream bovine growth hormone polyadenylation sequence, all under the control of the tetO, a tetracycline-responsive regulatory element (pTRE-Tight). The 1N4R isoform of human MAPT (microtubule-associated protein tau) contains an A152T substitution, converting GCC (Ala) at positions 454-456 to ACC (Thr). Founder line C11-1, also known as founder line L1, was established. (J:233816)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:233816 Maeda S, et al., Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016 Apr;17(4):530-51
All:	3 reference(s)