Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Tlr5tm1.2Gewr
Name:	toll-like receptor 5; targeted mutation 1.2, Andrew Gewirtz
MGI ID:	MGI:5780549
Gene:	Tlr5  Location: Chr1:182782353-182804010 bp, + strand  Genetic Position: Chr1, 86.12 cM
Alliance:	Tlr5tm1.2Gewr page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	iTL IC1 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A targeting vector was designed to place a loxP site upstream of exon 4, and a FRT::loxP::Neo::FRT::loxP cassette inserted 211 base pairs downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 4 floxed. Cre-mediated recombination removed exon 4. (J:229155)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tlr5 Mutation:	56 strains or lines available

Original:	J:229155 Chassaing B, et al., Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology. 2014 Dec;147(6):1363-77.e17
All:	4 reference(s)