Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ightm1.1Jwt
Name:	immunoglobulin heavy chain complex; targeted mutation 1.1, John Williams
MGI ID:	MGI:5780066
Synonyms:	VH125SD
Gene:	Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic

Germline Transmission:	Earliest citation of germline transmission: J:232773
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: The targeting construct replaces the IgJH loci with an anti-insulin rearranged VDJ-H-125 site. A loxP-flanked neomycin resistance cassette, in reverse orientation to the gene, is located upstream. Cre-mediated recombination removed the upstream floxed neo cassette. (J:232773)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:	43 strains or lines available

Original:	J:232773 Williams JM, et al., Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes. J Immunol. 2015 Aug 1;195(3):853-64
All:	4 reference(s)