Tg(CAG-C1qtnf3)1Gww
Transgene Detail
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| Symbol: |
Tg(CAG-C1qtnf3)1Gww |
| Name: |
transgene insertion 1, Guang William Wong |
| MGI ID: |
MGI:5771788 |
| Synonyms: |
CTPR3 Tg |
| Transgene: |
Tg(CAG-C1qtnf3)1Gww Location: unknown
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| Alliance: |
Tg(CAG-C1qtnf3)1Gww page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(CAG-C1qtnf3)1Gww expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
C1qtnf3 (MGI:1932136) |
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Mutation details: The cDNA sequence encoding mouse C1q and tumor necrosis factor related protein 3 (C1QTNF3; also called CTPR3) with a carboxy-terminal FLAG epitope (DYKDDDDK) tag was cloned into the pCAGGS vector downstream of the ubiquitously expressing "CAG promoter" - comprising the cytomegalovirus immediate early (CMV-EI) enhancer followed by the promoter, first exon and first intron of the chicken beta-actin gene with the 3' splice junction sequence replaced by that of the rabbit hemoglobin beta gene - and followed by the rabbit beta-hemoglobin polyadenylation signal. At the mRNA level, expression is observed in all tissues of transgenic mice analyzed by RT-PCR. The FLAG-tagged protein is detected by immunoblot analysis in heart, kidney, liver, and muscle, but not in adipose tissue or brain. Mice of the single maintained transgenic line exhibit greater than fivefold the wild-type level of circulating C1QTNF3 protein.
(J:205080)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:205080 Peterson JM, et al., CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 1;305(3):G214-24 |
| All: |
3 reference(s) |
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Analysis Tools
