Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Crkltm1Bem
Name:	v-crk avian sarcoma virus CT10 oncogene homolog-like; targeted mutation 1, Bernice E Morrow
MGI ID:	MGI:5763397
Synonyms:	Crkl-floxed, Crkl-NEO
Gene:	Crkl  Location: Chr16:17269851-17305298 bp, + strand  Genetic Position: Chr16, 10.82 cM
Alliance:	Crkltm1Bem page

Germline Transmission:	Earliest citation of germline transmission: J:230261
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 1. A floxed neomycin resistance cassette was inserted downstream of exon 1. RT-PCR confirmed reduced expression in E10.5 heart. (J:230261)

In Mice Carrying this Mutation:

19 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crkl Mutation:	15 strains or lines available

Original:	J:230261 Racedo SE, et al., Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Am J Hum Genet. 2015 Feb 5;96(2):235-44
All:	2 reference(s)