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Gene Expression Data
Assay Details
Assay
Reference: J:148786 Barber M, et al., The role of Robo3 in the development of cortical interneurons. Cereb Cortex. 2009 Jul;19 Suppl 1:i22-31
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5752757
Gene symbol: Calb1
Gene name: calbindin 1
Antibody: anti-Calbindin D28k (CB-38), rabbit
Detection system: Secondary antibody coupled to Alexa Fluor 568
Results
Specimen 3A: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present 3A Expressed in the cortical interneurons.
Specimen 3B: embryonic day 18.5; Robo3tm1Matl/Robo3tm1Matl (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present 3B Expressed in the cortical interneurons.
Specimen S2D: embryonic day 13.5; Robo3tm1Matl/Robo3+ (more )
Structure Level Pattern Image Note
TS21: cerebral cortex Present S2D Expressed in the cortical interneurons.
Specimen S2E: embryonic day 13.5; Robo3tm1Matl/Robo3tm1Matl (more )
Structure Level Pattern Image Note
TS21: cerebral cortex Present S2E Expressed in the cortical interneurons.
Specimen not shown: embryonic day 13.5; Robo3tm1Matl/Robo3+ (more )
Note: Data was summarized in Fig. 3C, 3D.
Structure Level Pattern Image Note
TS21: cerebral cortex Present Expressed in the cortical interneurons.
TS21: cerebral cortex marginal layer Present Expressed in the cortical interneurons.
Specimen not shown: embryonic day 13.5; Robo3tm1Matl/Robo3tm1Matl (more )
Note: Data was summarized in Fig. 3C, 3D.
Structure Level Pattern Image Note
TS21: cerebral cortex Present Expressed in the cortical interneurons. No significant changes in the total number of positive cells within rostral-middle or caudal levels, compared with the heterozygous control.
TS21: cerebral cortex marginal layer Present Expressed in the cortical interneurons. There was a significant reduction in the number of positive cells compared with heterozygote littermates in rostral-middle levels and caudal levels of the cortex.
Specimen not shown: embryonic day 18.5; Robo3tm1Matl/Robo3+ (more )
Note: Data was summarized in Fig. 3E, 3F.
Structure Level Pattern Image Note
TS26: cerebral cortex Present Expressed in the cortical interneurons.
Specimen not shown: embryonic day 18.5; Robo3tm1Matl/Robo3tm1Matl (more )
Note: Data was summarized in Fig. 3E, 3F.
Structure Level Pattern Image Note
TS26: cerebral cortex Present Expressed in the cortical interneurons. There was no differences in the number of positive cells in rostral-middle levels. A small but just significant decrease (11%) was observed within the caudal relative to heterozygote littermates.
Specimen not shown: embryonic day 13.5; Robo1tm1Wian/Robo1+, Robo2tm1.1Rilm/Robo2+, Robo3tm1Matl/Robo3tm1Matl (more )
Structure Level Pattern Image Note
TS21: cerebral cortex Present Expressed in the cortical interneurons.
Specimen not shown: embryonic day 13.5; Robo1tm1Wian/Robo1tm1Wian, Robo2tm1.1Rilm/Robo2tm1.1Rilm, Robo3tm1Matl/Robo3tm1Matl (more )
Structure Level Pattern Image Note
TS21: cerebral cortex Present Expressed in the cortical interneurons. There was a decrease in the total number of labeled cells relative to an animal which was heterozygote for both Robo1 and Robo2 receptors and fully deficient for the Robo3 receptor.
Specimen not shown: embryonic day 18.5; Robo3tm1Matl/Robo3+ (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present Expressed in the cortical interneurons.
Specimen not shown: embryonic day 18.5; Robo1tm1Wian/Robo1tm1Wian, Robo2tm1.1Rilm/Robo2tm1.1Rilm, Robo3tm1Matl/Robo3tm1Matl (more )
Structure Level Pattern Image Note
TS26: cerebral cortex Present Expressed in the cortical interneurons. Approximately 38%, 30% decrease in the number of positive cells within rostral-middle and caudal regions respectively, compared with a single Robo3 heterozygote littermate.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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