About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:174119 Glickstein SB, et al., Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsets. Cereb Cortex. 2007 Mar;17(3):632-42
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5751978
Gene symbol: Ccnd2
Gene name: cyclin D2
Antibody: Anti-Cyclin D2 (Ab-4 MS-221)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 3H/I: embryonic day 14.5 (more )
Note: Double labeled: red - Ccnd2; green - Ccnd1 (assay MGI:5751977).
Structure Level Pattern Image Note
TS22: ganglionic eminence Present Regionally restricted 3I , 3H In the ventricular zone, most progenitors expressed either Ccnd1 or Ccnd2, but a few cells expressed both cyclins. In the medial ganglionic eminence, immunopositive cells are predominantly in the subventricular zone.
TS22: medial ganglionic eminence Present Regionally restricted 3I , 3H In the ventricular zone, most progenitors expressed either Ccnd1 or Ccnd2, but a few cells expressed both cyclins. In the medial ganglionic eminence, immunopositive cells are predominantly in the subventricular zone.

Specimen 3K/L: embryonic day 14.5; Ccnd2tm1Wbg/Ccnd2tm1Wbg (more )
Note: Double labeled: red - Ccnd2; green - Ccnd1 (assay MGI:5751977).
Structure Level Pattern Image Note
TS22: ganglionic eminence Present Regionally restricted 3L , 3K In the ventricular zone, most progenitors expressed either Ccnd1 or Ccnd2, but a few cells expressed both cyclins. In the medial ganglionic eminence, immunopositive cells are predominantly in the subventricular zone.
TS22: medial ganglionic eminence Present Regionally restricted 3L , 3K In the ventricular zone, most progenitors expressed either Ccnd1 or Ccnd2, but a few cells expressed both cyclins. In the medial ganglionic eminence, immunopositive cells are predominantly in the subventricular zone.

Specimen S1B/C: embryonic day 14.5 (more )
Note: Double labeled: red - Ccnd2; green - Tbr1 (assay MGI:5752047).
Structure Level Pattern Image Note
TS22: cerebral cortex Present S1C , S1B Generally, expression was distinct from Tbr1 expression. Rare cells were seen that were labeled with both antibodies.

Specimen S1E/F: embryonic day 14.5 (more )
Note: Double labeled: red - Ccnd2; green - Tbr1 (assay MGI:5752047).
Structure Level Pattern Image Note
TS22: cerebral cortex Present S1E , S1F Generally, expression was distinct from Tbr1 expression. Rare cells were seen that were labeled with both antibodies.

Specimen S4A/C: embryonic day 12.5 (more )
Note: Double labeled: red - Ccnd2; green - Ccnd1 (assay MGI:5751977).
Structure Level Pattern Image Note
TS20: medial ganglionic eminence Present Regionally restricted S4C , S4A In the ventricular zone of the medial ganglionic eminence, most progenitors expressed either Ccnd1 or Ccnd2, but a few cells expressed both cyclins.

Specimen S4J/L: embryonic day 12.5 (more )
Note: Double labeled: red - Ccnd2; green - Olig2 (assay MGI:5752065).
Structure Level Pattern Image Note
TS20: medial ganglionic eminence Present Regionally restricted S4J , S4L Expression was detected in ventricular zone cells in the medial ganglionic eminence and colocalized with cells expressing Olig2. In the subventricular zone, cells expressed either Olig2 or Ccnd2.

Specimen S4N/O: embryonic day 14.5 (more )
Note: Double labeled: red - Ccnd2; green - Olig2 (assay MGI:5752065).
Structure Level Pattern Image Note
TS22: medial ganglionic eminence Present Regionally restricted S4N , S4O Expression was detected in ventricular zone cells in the medial ganglionic eminence and colocalized with cells expressing Olig2. In the subventricular zone, cells expressed either Olig2 or Ccnd2.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/07/2024
MGI 6.23
The Jackson Laboratory