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Gene Expression Data
Assay Details
Assay
Reference: J:105752 Wang Y, et al., The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci. 2006 Feb 22;26(8):2147-56
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5749547
Gene symbol: Fzd6
Gene name: frizzled class receptor 6
Antibody: Fz6 antibody
Results
Specimen 5F WT: embryonic day 18.0 (more )
Note: Double labeled with phalloidin (red). Flat mount.
Structure Level Pattern Image Note
TS26: organ of Corti Present Regionally restricted 5F WT Expression is in hair cells and supporting cells.
Specimen 5F Fz3-/-: embryonic day 18.0; Fzd3tm1Nat/Fzd3tm1Nat (more )
Note: Double labeled with phalloidin (red). Flat mount.
Structure Level Pattern Image Note
TS26: organ of Corti Strong Regionally restricted 5F Fz6-/- Expression is in hair cells and supporting cells.
Specimen 5F Fz6-/-: postnatal day 2; Fzd6tm1Nat/Fzd6tm1Nat (more )
Note: Double labeled with phalloidin (red). Flat mount.
Structure Level Pattern Image Note
TS27: organ of Corti Absent 5F Fz3-/-
Specimen 5F Lp/Lp: embryonic day 18.0; Vangl2Lp/Vangl2Lp (more )
Note: Double labeled with phalloidin (red). Flat mount.
Structure Level Pattern Image Note
TS26: organ of Corti Absent 5F Lp/Lp
Specimen 6B utricle Lp/Lp: embryonic day 18.5; Vangl2Lp/Vangl2Lp (more )
Note: Double labeled with phalloidin (red). Flat mounts.
Structure Level Pattern Image Note
TS26: utricle Absent 6B utricle Lp/Lp
Specimen 6B utricle Fz3-/-: embryonic day 18.5; Fzd3tm1Nat/Fzd3tm1Nat (more )
Note: Double labeled with phalloidin (red). Flat mounts.
Structure Level Pattern Image Note
TS26: utricle Present Regionally restricted 6B utricle Fz3-/- , 6B utricle merge Expression is localized to those sides of the polygonal epithelial cells that lie approximately at right angles to the hair bundle orientation.
Specimen 6B crista Lp/Lp: embryonic day 18.5; Vangl2Lp/Vangl2Lp (more )
Note: Double labeled with phalloidin (red). Flat mounts.
Structure Level Pattern Image Note
TS26: crista ampullaris Absent 6B crista Lp/Lp
Specimen 6B crista Fz3-/-: embryonic day 18.5; Fzd3tm1Nat/Fzd3tm1Nat (more )
Note: Double labeled with phalloidin (red). Flat mounts.
Structure Level Pattern Image Note
TS26: crista ampullaris Strong Regionally restricted 6B crista merge , 6B crista Fz3-/- Expression is localized to those sides of the polygonal epithelial cells that lie approximately at right angles to the hair bundle orientation.
Specimen not shown WT: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: crista ampullaris Present Regionally restricted Expression is at the plasma membrane in hair cells and supporting cells.
TS26: utricle Present Regionally restricted Expression is at the plasma membrane in hair cells and supporting cells.
Specimen 7A,C: postnatal day 0 (more )
Note: Double labeled with phalloidin (red).
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 7A , 7C Expression is near the apical surface of the sensory epithelia.
Specimen 7B,D: postnatal day 0; Fzd6tm1Nat/Fzd6tm1Nat (more )
Note: Double labeled with phalloidin (red).
Structure Level Pattern Image Note
TS27: organ of Corti Absent 7D , 7B
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory