Zbtb46tm3.1(cre)Mnz
Targeted Allele Detail
|
|
| Symbol: |
Zbtb46tm3.1(cre)Mnz |
| Name: |
zinc finger and BTB domain containing 46; targeted mutation 3.1, Michel C Nussenzweig |
| MGI ID: |
MGI:5749231 |
| Synonyms: |
zDCCre |
| Gene: |
Zbtb46 Location: Chr2:181029555-181101219 bp, - strand Genetic Position: Chr2, 103.63 cM, cytoband H4
|
| Alliance: |
Zbtb46tm3.1(cre)Mnz page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:230708
|
| Parent Cell Line: |
CY2.4 (ES Cell)
|
| Strain of Origin: |
B6(Cg)-Tyrc-2J
|
|
| Allele Type: |
|
Targeted (Recombinase) |
| Mutation: |
|
Insertion
|
| |
|
Zbtb46tm3.1(cre)Mnz expression driven by
1 gene
Knock-in expression driven by:
|
| |
|
Mutation details: An FRT-flanked neomycin resistance cassette and an IRES-Cre element were introduced to exon 5, immediately after the stop codon. Flp-mediated recombination removed the FRT-flanked neo cassette.
(J:230708)
|
|
|
|
Activity: |
 Tissue activity of this recombinase allele
|
|
Driver:
|
Zbtb46
(mouse)
|
|
User Notes:
|
Additional information submitted by the research community
Additional information submitted by the research community
An investigator using mice with this allele reports when crossed to mice with floxed allele, at least 95% of the offspring of female Cre+ mice carry germline deletions. In contrast, less than 5% of the offspring of male Cre+ mice carry germline deletions.
|
| |
|
|
|
|
| Original: |
J:230708 Loschko J, et al., Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation. J Exp Med. 2016 Apr 4;213(4):517-34 |
| All: |
16 reference(s) |
|
Analysis Tools