Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Prdm9tm1.1(PRDM9)Wthg
Name:	PR domain containing 9; targeted mutation 1.1, Benjamin Davies
MGI ID:	MGI:5708566
Gene:	Prdm9  Location: Chr17:15763341-15784616 bp, - strand  Genetic Position: Chr17, 8.95 cM
Alliance:	Prdm9tm1.1(PRDM9)Wthg page

Germline Transmission:	Earliest citation of germline transmission: J:228712
Parent Cell Line:	JM8.F6 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Prdm9tm1.1(PRDM9)Wthg expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human PRDM9 (56979) Prdm9  (MGI:2384854) mouse Zn-finger domain replaced with human   Mutation details: The region of exon 10 of the endogenous mouse gene that encodes the zinc-finger array has been replaced by the sequence of the corresponding region of human PRDM9 (reference allele, variant B); coding DNA upstream of the first zinc finger and the sequences downstream of the translation stop codon are of mouse origin. Single attP and frt sites, left by FLPe excision of a selection cassette, reside upstream and downstream, respectively, of the modified exon 10. (J:228712)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prdm9 Mutation:	46 strains or lines available

Original:	J:228712 Davies B, et al., Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 2016 Feb 11;530(7589):171-6
All:	3 reference(s)