Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Crhtm2(icre)Ksak
Name:	corticotropin releasing hormone; targeted mutation 2, Kenji Sakimura
MGI ID:	MGI:5707348
Synonyms:	CRF-iCre, Crhtm2(icre)Itoi
Gene:	Crh  Location: Chr3:19747565-19749560 bp, - strand  Genetic Position: Chr3, 5.75 cM
Alliance:	Crhtm2(icre)Ksak page

Germline Transmission:	Earliest citation of germline transmission: J:218341
Parent Cell Line:	RENKA (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Crhtm2(icre)Ksak expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Crh (MGI:88496)   Mutation details: A codon-optimized cre (icre) recombinase gene and neomycin resistance cassette were inserted downstream of the translation initiation site in exon 2. (J:218341)

Activity:	Tissue activity of this recombinase allele
Driver:	Crh (mouse) Summary of all recombinase alleles driven by Crh. Comparative matrix view of recombinase activities Alliance mouse Crh gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crh Mutation:	42 strains or lines available

Original:	J:218341 Itoi K, et al., Visualization of corticotropin-releasing factor neurons by fluorescent proteins in the mouse brain and characterization of labeled neurons in the paraventricular nucleus of the hypothalamus. Endocrinology. 2014 Oct;155(10):4054-60
All:	5 reference(s)