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Gene Expression Data
Assay Details
Assay
Reference: J:35634 Marcinkiewicz M, et al., Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin. Proc Natl Acad Sci U S A. 1993 Jun 1;90(11):4922-6
Assay type: RNA in situ
MGI Accession ID: MGI:5707150
Gene symbol: Pcsk2
Gene name: proprotein convertase subtilisin/kexin type 2
Probe: mPC2 probe1
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 2A: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: remnant of Rathke's pouch Present Regionally restricted 2A/A' Expression in the ventral bit of Rathkes pouch.

Specimen 2B: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: remnant of Rathke's pouch Weak Regionally restricted 2B/B' Lower levels of expression detected between E16 and E20.
TS24: adenohypophysis pars intermedia Present 2B/B' Expression first detected at E16.

Specimen 2C: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: remnant of Rathke's pouch Weak Regionally restricted 2C/C' Lower levels of expression detected between E16 and E20.
TS25: adenohypophysis pars intermedia Present 2C/C' Expression increased continuously throughout both prenatal and postnatal periods until adulthood.

Specimen 2D: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: remnant of Rathke's pouch Weak Regionally restricted 2D/D' Lower levels of expression detected between E16 and E20.
TS26: adenohypophysis pars intermedia Present 2D/D' Expression increased continuously throughout both prenatal and postnatal periods until adulthood.

Specimen 2E: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: adenohypophysis pars anterior Strong 2E/E' Expression increased to maximal levels during P1, P7 and P14.
TS27: adenohypophysis pars intermedia Present 2E/E' Expression increased continuously throughout both prenatal and postnatal periods until adulthood.

Specimen 2F: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars anterior Strong 2F/F' Expression increased to maximal levels during P1, P7 and P14.
TS28: adenohypophysis pars intermedia Present 2F/F' Expression increased continuously throughout both prenatal and postnatal periods until adulthood.

Specimen 2G: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars anterior Strong 2G/G' Expression increased to maximal levels during P1, P7 and P14.
TS28: adenohypophysis pars intermedia Present 2G/G' Expression increased continuously throughout both prenatal and postnatal periods until adulthood.

Specimen 2H: postnatal adult (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars anterior Present 2H/H' Expression decreased until adulthood.
TS28: adenohypophysis pars intermedia Present 2H/H' Expression increased continuously throughout both prenatal and postnatal periods until adulthood.

Specimen Table 1 E11: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: future neurohypophysis Absent

Specimen Table 1 E12: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: adenohypophysis pars anterior Absent
TS20: adenohypophysis pars intermedia Absent

Specimen Table 1 E13: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: adenohypophysis pars anterior Absent
TS21: adenohypophysis pars intermedia Absent

Specimen Table 1 E14: embryonic day 14.0 (more )
Structure Level Pattern Image Note
TS22: adenohypophysis pars anterior Absent
TS22: adenohypophysis pars intermedia Absent

Specimen Table 1 E15: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: adenohypophysis pars intermedia Absent
TS23: adenohypophysis pars anterior Trace

Specimen Table 1 E16: embryonic day 16.0 (more )
Structure Level Pattern Image Note
TS24: adenohypophysis pars intermedia Weak
TS24: adenohypophysis pars anterior Trace

Specimen Table 1 E17: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: adenohypophysis pars intermedia Weak
TS25: adenohypophysis pars anterior Trace

Specimen Table 1 E18: embryonic day 18.0 (more )
Structure Level Pattern Image Note
TS26: adenohypophysis pars intermedia Present
TS26: adenohypophysis pars anterior Trace

Specimen Table 1 E20: embryonic day 20.0 (more )
Structure Level Pattern Image Note
TS26: adenohypophysis pars intermedia Present
TS26: adenohypophysis pars anterior Trace

Specimen Table 1 P1: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: adenohypophysis pars intermedia Strong
TS27: adenohypophysis pars anterior Weak

Specimen Table 1 P7: postnatal day 7 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Strong
TS28: adenohypophysis pars anterior Present

Specimen Table 1 P14: postnatal day 14 (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Very strong
TS28: adenohypophysis pars anterior Strong

Specimen Table 1 Adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: adenohypophysis pars intermedia Very strong
TS28: adenohypophysis pars anterior Weak


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory